The final scene of Call of Duty: Modern Warfare 2's campaign sees Kate Laswell debriefing the team over a drink at a local bar. Laswell tells Captain Price that General Shepherd is still at large, with his private military company, Shadow Company, likely protecting him.

The Modern Warfare 2 campaign has 17 missions, and as with previous Call of Duty campaigns, the action is split across various continents and gameplay types as it jumps between the perspectives of multiple characters.