Zombi 2 serves as a sequel to Zombi, a re-edited European release of George A. Romero's 1978 film Dawn of the Dead. Zombi had been edited by Dario Argento and given a new score by the Italian band Goblin, and proved successful upon its release in Italy.

The film is produced and distributed by The Asylum and was released on March 1, 2024. A prequel, Zoombies 2 was released on March 26, 2024, while a spin-off film, Aquarium of the Dead, was released on May 21, 2024.